This page contains temporary information about bortezomib and a collection of hyperlinks to much more details about the use of this drug, study final results, and ongoing clinical trials.
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You'll find stories of quite a few lethal results from bortezomib overdose. When the affected individual ordeals an overdose, close checking in the ICU is usually recommended. Intense hydration and servicing of standard overall body temperature are very important.
lorlatinib will lower the extent or effect of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
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ceritinib will enhance the level or result of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
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Bortezomib really should be withheld for the onset of grade three non-hematological or quality 4 hematological toxicity until finally Ritobegron HCl the Atpenin A5 toxicity resolves. Remedy is then remedy restarted in a lessen modified dose. There is not any antidote available to reverse the toxic consequences of your drug.
darunavir will boost the amount or impact of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
tell your health care provider if you are Expecting or program to become Expecting. Bortezomib could hurt the fetus. Use start Manage to prevent pregnancy during your procedure with bortezomib and for at least seven months immediately after your ultimate dose. In case you are a male having a feminine companion who could become pregnant, make sure to use start Handle throughout your procedure with bortezomib and for at least 4 months immediately after your last dose.
Bortezomib is indicated for the cure of adults with many myeloma or mantle cell lymphoma.11
cenobamate will enhance the degree or outcome of bortezomib by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Closely. Look at a dose reduction of CYP2C19 substrates, as clinically suitable, when made use of concomitantly with cenobamate.
bortezomib will increase the stage or impact of mavacamten by influencing hepatic enzyme CYP2C19 metabolism. Contraindicated. Robust or Lp-PLA2-IN-1 average CYP2C19 inhibitors may possibly improve mavacamten systemic publicity, causing heart failure due to systolic dysfunction.